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Literature summary extracted from

  • Nakamura, Y.; Hornsby, P.; Casson, P.; Morimoto, R.; Satoh, F.; Xing, Y.; Kennedy, M.; Sasano, H.; Rainey, W.
    Type 5 17ß-hydroxysteroid dehydrogenase (AKR1C3) contributes to testosterone production in the adrenal reticularis (2009), J. Clin. Endocrinol. Metab., 94, 2192-2198.
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.64 Homo sapiens
-
-
-
1.1.1.239 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.64 adrenal gland predominantly expressed in the zona reticularis Homo sapiens
-
1.1.1.64 liver
-
 Homo sapiens
-
1.1.1.64 ovary
-
 Homo sapiens
-
1.1.1.64 testis
-
 Homo sapiens
-
1.1.1.239 adrenal gland predominantly expressed in the zona reticularis Homo sapiens
-
1.1.1.239 liver
-
 Homo sapiens
-
1.1.1.239 ovary
-
 Homo sapiens
-
1.1.1.239 testis
-
 Homo sapiens
-

Synonyms

EC Number Synonyms Comment Organism
1.1.1.64 17beta-hydroxysteroid dehydrogenase type 5
-
 Homo sapiens
1.1.1.64 AKR1C3
-
 Homo sapiens
1.1.1.239 17beta-hydroxysteroid dehydrogenase type 5
-
 Homo sapiens
1.1.1.239 AKR1C3
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
1.1.1.63 malfunction AKR1C3 knockdown is accomplished in cultured adrenal cells (H295R) using small interfering RNA. Decreasing adrenal cell expression of AKR1C3 mRNA and protein inhibit testosterone production in the H295R adrenal cell line Homo sapiens
1.1.1.64 malfunction AKR1C3 knockdown is accomplished in cultured adrenal cells (H295R) using small interfering RNA. Decreasing adrenal cell expression of AKR1C3 mRNA and protein inhibit testosterone production in the H295R adrenal cell line Homo sapiens